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Clindets (Cleocin)

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Clindets is used for treating serious infections caused by certain bacteria. Clindets is a lincomycin antibiotic. Clindets kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Other names for this medication:
Antirobe, Basocin, Chloramphenicol, Clendix, Cleocin, Climadan, Clinacin, Clinda, Clindacin, Clindacne, Clindagel, Clindahexal, Clindal, Clindamax, Clindamicina, Clindasol, Clindasome, Clindesse, Clinium, Clinsol, Clinwas, Cutaclin, Dalacin, Dentomycin, Derma, Dermabel, Evoclin, Klimicin, Klindamicin, Klindan, Mediklin, Sobelin, Tidact, Ziana, Zindaclin

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Also known as:  Cleocin.


Clindets is a prescription medication used to treat bacterial infections of the lungs, skin, blood, bones, joints, female reproductive system, and internal organs.

Clindets belongs to a group of drugs called lincomycin antibiotics. These work by stopping the growth of bacteria.

This medication is available as a vaginal cream, vaginal suppository, oral capsule, and oral liquid.

This medication is also available in injectable forms to be given directly into a vein (IV) or a muscle (IM) by a healthcare professional.

Common side effects of Clindets include nausea, vomiting, joint pain, heartburn, pain when swallowing, and white patches in the mouth.


Take Clindets exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Take the capsule with a full glass of water to keep it from irritating your throat.

Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Clindets is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

To make sure this medicine is not causing harmful effects, you may need frequent medical tests during treatment.

If you need surgery, tell the surgeon ahead of time that you are using Clindets.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Clindets will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.

Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.


In the event the patient misses a dose of Clindets, the patient should take it as soon as possible. However, if it is almost time for the next scheduled dose, taking another dose of Clindets may cause an overdose which can lead to serious health complications. In this case, the missed dose should be skipped entirely to avoid an overdose potential. If an overdose of Clindets is suspected the patient should seek immediate medical intervention and assessment. An overdose may involve symptoms such as changes in mood or behaviors, thoughts of self harm, suicidal thoughts, seizures, or convulsions.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Clindets are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Generic Clindets if you are allergic to Generic Clindets components or to to tartrazine.

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Try to be very careful with Generic Clindets if it is given to children younger than 10 years old who have diarrhea or an infection of the stomach or bowel. Elderly patient should use Generic Clindets with caution.

Be sure to use Generic Clindets for the full course of treatment.

Avoid alcohol.

It can be dangerous to stop Generic Clindets taking suddenly.

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Minimum inhibitory concentrations were determined for selected antimicrobial agents against 872 bacteria isolated from intramammary infections in heifers in New Zealand (n = 401) and Denmark (n = 471). These values were reported in micrograms per milliliters. Antimicrobial agents tested against isolates from New Zealand were penicillin, cloxacillin, cephapirin, ceftiofur, novobiocin, enrofloxacin, erythromycin, and pirlimycin. The minimum inhibitory concentrations that inhibit 90% of the strains tested for these antimicrobial agents with Staphylococcus aureus were 4.0, 0.5, 0.5, 2.0, 1.0, 0.25, 0.5, and 1.0, respectively. The minimum inhibitory concentration values that inhibit 90% of the strains tested against the Staphylococcus spp. ranged from 0.5 to 1.0 for all antimicrobics. The minimum inhibitory concentrations against streptococci were < or = 0.06, 0.5, 0.13, 0.13, 4.0, 1.0, 0.13, and < or = 0.06, respectively. Antimicrobial agents tested against isolates from Denmark included penicillin, ampicillin, oxacillin, cephalothin, ceftiofur, penicillin plus novobiocin, erythromycin, and pirlimycin. Against S. aureus, the minimum inhibitory concentrations were 0.13, 0.5, 0.5, 0.5, 1.0, 0.25, 0.5, and 0.5, respectively. The minimum inhibitory concentrations against Staphylococcus spp. were 0.25, 0.25, 0.5, 0.5, 1.0, < or = 0.06, 0.13, 1.0, and 0.5, respectively. The minimum inhibitory concentrations against the streptococci were < or = 0.06, 0.13, 0.5, 0.5, 1.0, < or = 0.06, 0.13, 0.5, and 0.5, respectively. Minimum inhibitory concentration values for staphylococci from New Zealand and Denmark were similar to values reported for US isolates. Streptococci from New Zealand and Denmark had lower minimum inhibitory concentration values than did US isolates. Only ceftiofur and enrofloxacin were active against the Gram-negative bacilli.

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A post hoc analysis in 72 adult female patients (aged ≥25 years) with moderate-to-severe acne receiving clindamycin phosphate 1.2%/benzoyl peroxide 3.75% gel or vehicle for 12 weeks.

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Two hundred seventy-five surveys were returned. The EMPs used a variety of approaches in the antibiotic treatment of skin and soft tissue infections. Two hundred seven (75.3%) of 275 were board-certified EMPs and were included in the analysis. Commonly used agents for outpatient treatment include trimethoprim/sulfamethoxazole, clindamycin, cephalexin, rifampin, and tetracyclines. For patients requiring admission, 60% of providers would include vancomycin in their treatment regimen.

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Pneumococcal isolates were prospectively collected by 14 different clinical microbiology laboratories. Minimal inhibitory concentrations of penicillin G, erythromycin A, clarithromycin, roxithromycin, azithromycin, clindamycin, levofloxacin and telithromycin were determined by the broth microdilution method.

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The correct surveillance and control of infection caused by methicillin-resistant Staphylococcus aureus (MRSA) needs of update knowledge of its specific properties in each place. Our study aims to describe the current characteristics of infection due to MRSA in Extremadura. During 2010, 309 MRSA were collected from clinical samples in our region. A susceptibility test that included 17 antibiotics tested by AST -588 card Vitek 2 ® and E -test method was performed on all isolates. A sample of 100 strains, selected by stratified random sampling, were genotyped by pulsed field electrophoresis (PFGE). The prevalence of MRSA in Extremadura was 20.2%. Don Benito-Villanueva area showed the most prevalence and a higher incidence. Merida reported the most favourable situation, with a relatively low ratios of prevalence and incidence. The community acquired reached 44 % in the region, showing predominantly in less populated areas (Navalmoral and Coria). The most common multiresistant pattern was tobramycin-levofloxacin-erythromycin (44%), followed tobramycin-erythromycin-clindamycin (20%). No linezolid, daptomycin and tigecycline resistant strains were observed, but 42 % of the MRSA strains showed decreased susceptibility vancomycin (DSV). PFGE analysis reported 27 genotypes, with 3 major genotypes: E8a (25%), E7b (17%) and E7a (12%). The post-hoc statistical analysis did not reveal significant differences in the distribution of genotypes between different areas. However it revealed some trends that should be considered.

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The therapeutic efficacy of ciprofloxacin in the treatment of experimental intra-abdominal abscesses in mice caused by a strain of Staphylococcus epidermidis was compared with that of ampicillin and clindamycin. The abscesses were produced by intraperitoneal administration of a bacterial suspension obtained by bacterial culture of S epidermidis diluted to 10(8) CFU/ml mixed with sterilized rat feces and barium sulphate in male BALB/C mice. The following doses of antibiotics were given twice a day for seven days: ciprofloxacin, 1 microgram/100 microliters; clindamycin, 1.5 micrograms/100 microliters; and ampicillin, 3.6 micrograms/100 microliters. The antibiotic serum and pus concentrations were also determined by an agar well diffusion assay. The maximum serum concentrations were obtained 30 minutes after intraperitoneal administration (ciprofloxacin, 2.7 micrograms/ml; clindamycin, 9.0 micrograms/ml; ampicillin, 3.9 micrograms/ml). The penetration inside the abscess was also satisfactory (ciprofloxacin, 0.51 microgram/ml; clindamycin, 3.4 micrograms/ml; ampicillin, 3.8 micrograms/ml). A favorable clinical and bacteriologic response was obtained in 69% of the mice following the ciprofloxacin treatment and in 56% following ampicillin. The efficacy of ciprofloxacin was much higher than that of clindamycin and ampicillin, presumably because of its much higher intrinsic potency against the pathogen rather than for its pharmacokinetic characteristics and its penetration inside the abscess.

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The authors discuss the reasons for the frequently fatal outcome of infections in the newborn and report their own bacteriological findings in cases of perinatal infections. The predominant organisms were group D streptococci, staphylococcus aureus, E. coli, and anerobic bacteria, most of which were sensitive to clindamycin. Following introduction of clindamycin therapy, in combination with an aminoglycoside or ampicillin, the duration of hospitalization was shortened by an average of six days, and the duration of treatment by an average of three days.

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Immunocompromised people who are infected by B. microti are at risk of persistent relapsing illness. Such patients generally require antibabesial treatment for >or=6 weeks to achieve cure, including 2 weeks after parasites are no longer detected on blood smear.

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Deep neck infections are not Thuoc Trifamox 500 Mg unusual in either the pediatric or adult populations. Multiple, and recurrent abscesses are found not infrequently, especially in immunocompromised and debilitated persons. It is very rare to find sequential parapharyngeal abscesses without identifiable etiology in an otherwise healthy pediatric patient while receiving appropriate, culture-directed, intravenous antibiotics. This could be due to underestimation of the extent of the infection by CT scanning. The use of intravenous clindamycin as a first-line therapy may not be sufficient if a large phlegmon exists. We describe a case of sequential, bilateral parapharyngeal abscesses in a 3-year-old patient.

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Propionibacterium acnes is the target of antimicrobial treatments for acne vulgaris. Acquired resistance to erythromycin, clindamycin and tetracyclines has been reported in strains from diverse geographical loci, but the molecular basis of resistance, via mutations Suprax 200 Mg Price in genes encoding 23S and 16S rRNA, respectively, has so far only been elucidated for isolates from the U.K.

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Bacteroides fragilis group isolates from 37 laboratories in 19 countries were biochemically characterized. The MICs of seven antimicrobial agents were determined by the agar dilution method as recommended by Dosis Elequine 750 Mg the NCCLS. Production of beta-lactamase was detected by nitrocefin.

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Despite prophylactic antibiotic use in abdominal trauma patients, infection rates remain high. A previous study from our institution indicated that higher doses of prophylactic antibiotics in trauma patients could significantly reduce subsequent Avelox Dose For Dogs infection rates. To determine if this resulted from altered pharmacokinetic profiles, we performed individualized pharmacokinetic analysis of the prophylactic amikacin regimens given to 28 trauma patients undergoing laparotomy. Patients were prospectively randomized to receive a standard regimen of 11 mg/kg of amikacin every 12 hours or to have their regimens adjusted based upon pharmacokinetic analysis. Repeated pharmacokinetic analyses were performed daily for the three-day prophylactic regimen. There was a significant expansion in the apparent volume of distribution for amikacin that correlated with fluid resuscitation. This, along with increased elimination rates, helps to explain the failure to achieve adequate amikacin levels using standard regimens in trauma patients. Such underdosing may contribute to relatively high infection rates following major abdominal injury.

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A total of 100 Streptococcus pneumoniae strains with various penicillin G susceptibilities, isolated in Barcelona, Spain, from different pediatric sources during 1983 and the first 4 months of 1984, were tested for susceptibility to tetracycline, chloramphenicol, erythromycin, clindamycin, vancomycin, and rifampin. The isolates were distributed in nine patterns of antibiotic resistance, and 15 different serotypes were encountered. The high incidence of resistance to multiple antibiotics clearly indicates the need to perform antibiotic susceptibility testing of all pneumococcal isolates with proved pathologic Tab Ciplin Ds significance to avoid therapeutic failure.

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Combination therapy with vancomycin and clindamycin was associated with decreased hospital LOS for patients with Bactrim 320 Mg an abscess. The 90-day hospital readmission rates for those with ABSSSIs may be reduced when combination therapy is utilized. A larger, prospective, multicentered study is needed to validate these findings.

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Streptococci are a genus of Gram-positive bacteria which cause diverse human diseases. Many of these species have the Cedrox Dose potential to cause invasive infection resulting from the presence of bacteria in a normally sterile site.

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Laboratory of Cleocin Where To Buy Clinical Microbiology and Antibiotic Centre, Department of Clinical Biochemistry and Laboratory Diagnostics, General Teaching Hospital, Prague.

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Many mandible fractures are treated using open reduction internal fixation (ORIF) because of its superior stabilization of the fracture line, better healing, and faster recovery while minimizing the duration of immobilization of the mandible. However, ORIF requires an incision, which can lead to one of the most common complications of a mandibular fracture repair: postoperative wound infection. Historical controls have shown the infection rate after such surgeries to be anywhere from 6% to 32%. Most of the infections are due to normal oral flora, which is a mix of diverse facultative and obligate anaerobes. The current study was undertaken to determine whether a specific antibiotic regimen should be recommended to cover the normal flora. A retrospective review of 79 patients treated with ORIF mandibular repair was completed. The overall infection rate with use of antibiotic prophylaxis was 7.59%, but patients treated with clindamycin had an infection rate of 19.35%. The infection rate when using ampicillin/sulbactam was significantly lower than clindamycin. On the Amoxiclav 1 Mg basis of this review, proper antibiotic prophylaxis should cover both potential aerobes and anaerobes.

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Clindamycin continues to be an important agent for the management of infections due to gram-positive cocci and anaerobes. Such pathogens are frequently important in skin, soft tissue, and deep infections of the foot. Erythromycin has an impressive safety record and has retained its activity against many organisms, including several that play a role in infections of the foot. Clindamycin and erythromycin are frequently used as alternatives to the penicillins and cephalosporins. Newer macrolides, in comparison to erythromycin, have similar antimicrobial spectra of activity, improved pharmacokinetic parameters, and better tissue penetration. As new microorganisms emerge as clinical Synulox 500 Mg problems, newer macrolides may play a therapeutic role.

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This rapid and simple assay can predict in vitro susceptibility to clindamycin within two hours of isolation as opposed to 18-24 hours via disk diffusion. The assay might also be used to screen large numbers of batched isolates to establish the prevalence of resistance in a Ceftin 500 Mg Cefuroxime given area.