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Topcef (Cefixime)

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Topcef is a third generation oral bactericidal cephalosporin. Mechanism of action of Topcef is similar to penicillin. Topcef acts by inhibiting bacterial cell wall synthesis. Lack of bacterial cell wall results in death due to lysis of bacteria. Topcef is used in treatment of uncomplicated urinary tract infections, otitis media, acute bronchitis, acute exacerbation of chronic bronchitis, uncomplicated gonorrhoea.

Other names for this medication:
Cefix, Cefixima, Cefixime, Cefspan, Ceftas, Denvar, Hifen, Mahacef, Milixim, Novacef, Omnicef, Omnix, Oroken, Suprax, Taxim, Tricef, Unixime, Ziprax

Similar Products:
Amoxil, Moxatag, Trimox, Acticlate, Adoxa, Alodox, Avidoxy, Doryx, Monodox, Levaquin, Cipro

Also known as:  Cefixime.


Topcef is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Topcef is used to treat many different types of infections caused by bacteria.

Topcef may also be used for purposes not listed in this medication guide.

You should not take this medicine if you are allergic to Topcef, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to penicillins.


Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

Topcef works best if you take it with a meal or within 30 minutes of a meal.

The Topcef chewable tablet must be chewed before you swallow it.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Topcef.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Topcef will not treat a viral infection such as the common cold or flu.

Store the tablets and capsules at room temperature away from moisture, heat, and light.

Store the oral liquid in the refrigerator. Throw away any unused medication after 14 days.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Topcef are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Generic Topcef if you are allergic to Generic Topcef components or to other cephalosporins (eg, cephalexin).

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Do not use Generic Topcef if you will be having a live typhoid vaccine.

Try to be careful with Generic Topcef usage in case of having kidney or liver disease, nerve disorders, epilepsy, leukopenia, anemia, seizure disorder, stomach or intestinal disease, blood cell disorder.

Try to be careful with Generic Topcef usage in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

Try to be careful with Generic Topcef usage in case you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin (eg, amoxicillin) or beta-lactam antibiotic (eg, imipenem).

Try to be careful with Generic Topcef usage in case you have diarrhea, stomach or bowel problems (eg, inflammation), bleeding or blood clotting problems, liver problems, or poor nutritionhistory of kidney problems or you are on dialysis treatment.

Try to be careful with Generic Topcef usage in case you take anticoagulants (eg, warfarin) or carbamazepine because the risk of their side effects may be increased by Generic Topcef; live typhoid vaccines because their effectiveness may be decreased by Generic Topcef.

Avoid alcohol.

It can be dangerous to stop Generic Topcef taking suddenly.

is topcef antibiotic

Seven electronic databases for articles published between 1966 and March 1999 and reference lists in proceedings, published articles, reports, and guidelines.

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The Hungarian national guidelines for the treatment of gonorrhoea were published in 2002 but are now widely considered to be outdated. Improved knowledge is needed with respect to the epidemiology and antimicrobial susceptibility of Neisseria gonorrhoeae strains currently circulating in Hungary not least for the construction of updated local recommendations for treating gonorrhoea. European guidelines are based mostly on western European data raising concerns locally that recommended treatments might not be optimised for the situation in Hungary. We report our recent study on the distribution of antibiotic resistance in various Hungarian (East European) Neisseria gonorrhoeae strains isolated from patients with gonorrhoea over the past four years.

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A few studies are available comparing either minimum inhibitory concentration (MIC) values with the Clinical and Laboratory Standards Institute (CLSI) disc diffusion method or MIC with the Australian Gonococcal Surveillance Program (AGSP) method.

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Although a ciprofloxacin dose-response was not detected, 250 mg was used in most of the studies. Among 815 patients with 910 infected sites receiving 250 mg of ciprofloxacin, bacteriologic eradication was achieved in 563 (100%) male urethral, 199 (100%) female cervical, 101 (99%) male and female rectal, and 47 (96%) male and female pharyngeal sites.

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The spread of antimicrobial-resistant Neisseria gonorrhoeae worldwide is a critical issue in the control of sexually transmitted infections. The purpose of this study was to clarify recent trends in the susceptibility of N. gonorrhoeae to various antimicrobial agents and to compare these data with our previous data. Minimum inhibitory concentrations (MICs) of various antimicrobial agents were determined in N. gonorrhoeae strains clinically isolated from male gonococcal urethritis. In addition, amino acid sequencing of penicillin-binding protein (PBP) 2, encoded by the penA gene, was analyzed so that genetic analysis of mosaic PBP 2 could clarify the susceptibility of the strains to cefixime and other cephalosporins. The susceptibility rate for ceftriaxone, cefodizime, and spectinomycin, agents whose use is recommended by the guideline of the Japanese Society of Sexually Transmitted Infections (JSSTI), was 100 %. The susceptibility rates of the strains to penicillin G and ciprofloxacin were lower than those in previous reports. Mosaic PBP 2 structures were detected in 51.9 % of the strains and the MICs of the strains with the mosaic PBP 2 to cefixime were much higher than those of the strains without the mosaic PBP 2. In the clinical situation, the treatment regimen recommended by the JSSTI remains appropriate; however, the susceptibility to cephalosporins should be intensively surveyed because strains with mosaic PBP 2 were commonly detected.

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To assess the spontaneous clearance of untreated Chlamydia trachomatis infections and factors correlated with the process.

topcef medicine

The mechanism of action of a new orally active cephalosporin, FK027, was compared to that of cephalexin and cefaclor to elucidate its excellent antibacterial activity against Gram-negative bacteria. FK027 showed very high affinity for the penicillin-binding proteins (PBPs) 3, 1a and 1bs of Escherichia coli whereas cephalexin showed fairly high affinity for PBPs 1a, 4 and 3. The ability of FK027 to penetrate the outer membranes of E. coli and Enterobacter cloacae was less than that of cephalexin and cefaclor. However, FK027 was extremely stable to both plasmid-mediated penicillinases and chromosomal beta-lactamases except the Bacteroides fragilis enzyme and its stability was superior to that of cephalexin and cefaclor. These results indicate that the potent antibacterial activity of FK027 is based on its enhanced affinity for the target enzymes and its high stability to beta-lactamases.

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Data are presented on the in vitro microbiologic activity of cefprozil against 10,152 bacterial isolates, including most of the clinically important streptococci (e.g., Streptococcus pyogenes, Streptococcus pneumoniae), beta-lactamase-positive and -negative Staphylococcus aureus and Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Clostridium difficile, and numerous other gram-negative aerobes and anaerobes. In clinical trials, cefprozil appears to be at least as effective as commonly used comparison agents such as cefaclor, cefixime, and amoxicillin/clavulanic acid. Additionally, cefprozil is better tolerated than the latter two agents, especially with regard to gastrointestinal adverse effects.

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Cefixime is a new third generation oral cephalosporin that exhibits excellent antibacterial activity against Neisseria gonorrhoeae, including beta-lactamase-positive strains. In an open uncontrolled clinical trial 14 male patients suffering from acute gonorrhea, aged 23 to 48 years, were treated with a single dose of 400 mg of cefixime. All 13 fully evaluable patients were clinically and bacteriologically cured. Side effects were not reported.

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topcef clav 200 mg 2016-10-12

For the period 1997-2003, data on outpatient use of systemic cephalosporins aggregated at the level of the active substance were collected and expressed in DDD (WHO, version 2004) per 1000 inhabitants per day (DID). Use was analysed in detail, using the new ATC codes J01DB, J01DC, J01DD and J01DE, introduced in the 2005 issue of the WHO ATC index and Penamox 250 Mg Pediatrico assigned to the four cephalosporin generations.

topcef medicine 2015-04-04

The results clearly demonstrate, under the conditions of this study, that BPW without antibiotics Levaquin 750mg Levofloxacin Antibiotics was the superior pre-enrichment medium for the isolation of E. coli O157 from cattle faeces.

topcef antibiotic 2017-04-05

Gonorrhoea has been among the easiest infections to cure with Flagystatin Capsule 500g antibiotics. Nevertheless, emerging resistance has driven repeated treatment shifts. Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and undertook pharmacodynamic analyses to predict efficacy against strains with raised MICs.

topcef dose 2015-10-07

The most frequent types found were ST 1407, ST 5405, ST 2992, and ST 5120. If CLSI and EUCAST criteria were applied, an ST 9807 type was found non-susceptible to ceftriaxone and cefixime (MIC 0.5μg/mL). When only EUCAST breakpoints were taken into account, three strains were also resistant to cefixime (MIC 0.25μg/mL) and two isolates were resistant to ceftriaxone (MIC 0.19 and 0.25μg/mL, respectively). The majority Color Of Azithromycin Tablet of strains were resistant to ciprofloxacin, and all Neisseria gonorrhoeae strains were susceptible to spectinomycin; twenty-five percent of isolates were resistant to azithromycin.

topcef 200 tablet usage 2016-07-15

Cefpodoxime has been found to be a Amoxiplus 1000 Mg well-tolerated and superior alternative to cefixime synergistically documenting the extended spectrum of activity.

topcef o tablet 2016-03-10

Oral cefixime or ceftriaxone injections were used as first-line drugs for the treatment of gonorrhea from Cefixime Buy Online 2006 to 2013 because gonorrhea isolates had low minimum inhibitory concentrations for these two drugs. The abrupt emergence of ST4378 (closely related to the notorious ST1407) since 2009 is a cause for alarm. Changes in sexual behavior, including an increase in sexual activity without the use of condoms, may have contributed to the peak in gonorrhea in 2010. Further molecular epidemiological investigations are required.

topcef 100 mg 2016-04-01

Emerging resistance in all bacterial STIs and the particular problem of Antirobe Cats Dosage resistant gonorrhoea will present a challenge to maintain antimicrobial therapy at the forefront of public health control.

purpose of topcef medicine 2016-12-20

Out of the 450 S. aureus isolates 174 (38.6%) were found to be MRSA. In those isolates, high resistance was found to Cefixime (100%) Doxicycline (100%) Oxacillin (96.5%) Gentamicin, (96.3%), Timethoprim/Sulfametoxazole (95.6%) Chloramphenicol (93%) Tobramicin (81.03%), Ofloxacin (72.4%) and Ciprofloxacin (63.7%). Low resistance was found to Ceftazidine (36%), Amoxicillin/Clavulanate (32.7%), Fosfomycin (31%), Cefroxime (24%), Amikacin (17.2%) and Meropenem (13%). One isolate was found to be Vancomycin resistant (MIC 32 μg/ml). Four isolates had intermediate resistance, with two strains having MIC of 16μg/ml and two having MIC of 8μg/ml. These strains were also resistant to Cleocin Phosphate 600 Mg all the other tested antibiotics except Linezolid to which all isolates were susceptible.

topcef syrup 2015-07-15

To investigate the molecular epidemiology Cleocin Antibiotic Cream of isolates of Neisseria gonorrhoeae from Saskatchewan, Canada, using Neisseria gonorrhoeae multi antigen sequence typing (NG-MAST), and to assess associations between antimicrobial susceptibility (AMS) and specific strain types (STs).

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Growth of VTEC during enrichment is dependent on different factors alone or in combination. These include medium type, presence Clinda Gel Pantip of certain selective agents or antibiotics, incubation temperature and the initial population of VTEC. Sensitivity to these conditions can be strain related.